Publication in Angewandte Chemie Int. Ed.
Check out our most recent publication in Angewandte Chemie Int. Ed. on palladacarboxamide capping reagents for carbon isotope labeling and pharmaceutical diversification.
In this work, we present a method for carbon isotope labeling of arylamides via the coupling of air-stable palladium carboxamide complexes and boronic ester/acids. A wide variety of functionalized boronic esters and acids have been coupled with simple palladium carboxamides complexes. Further development led to late-stage derivatization of small amine-displaying drug molecules and the direct 14C-isotope labeling of these derivatives.